Is Vitamin D Safe with ACE Inhibitors (class)?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Patients on ACE inhibitors who are vitamin D deficient can still benefit from vitamin D supplementation; monitor serum 25(OH)D levels periodically to confirm adequacy (target >30 ng/mL) and emphasize adherence as the strongest predictor of achieving adequate levels.
Why this interaction occurs
A prospective 12-month study showed that vitamin D supplementation effectively improved serum 25(OH)D levels in ACE inhibitor users, indicating no clinically significant inhibitory interaction. However, outcomes varied by comorbidity and medication class, warranting personalized monitoring.
Evidence
Evidence level: moderate.
Data source
PubMed - PMID 41304971
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 5,699,337 reports mentioning ACE Inhibitors (class). This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the ACE Inhibitors (class) + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Vitamin D interactions → · All ACE Inhibitors (class) interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.