Is Vitamin D Safe with Benazepril?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Vitamin D supplementation at moderate doses (1000-2000 IU/day) is generally safe and may offer cardiovascular benefits alongside benazepril. However, avoid high-dose supplementation without monitoring, and inform your provider of all supplements taken.
Why this interaction occurs
Vitamin D regulates the renin-angiotensin system by suppressing renin synthesis. Combined with ACE inhibitors, this dual suppression of RAAS may theoretically enhance blood pressure lowering effects. Additionally, ACE inhibitor use may impair vitamin D metabolism in some patients, and vitamin D sufficiency may improve outcomes in hypertensive patients on ACE therapy.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 20,900 reports mentioning Benazepril. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Benazepril + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Vitamin D interactions → · All Benazepril interactions →
Already checked this one — check your whole list
Educational only — not medical advice.
Always confirm with your doctor or pharmacist.