Is Zinc Safe with Captopril?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Consider supplementing with zinc 15-25 mg daily, taken at least 2 hours apart from Captopril. Have zinc levels monitored periodically by your healthcare provider.
Why this interaction occurs
Captopril contains a sulfhydryl group that directly chelates zinc, forming a zinc-captopril complex excreted in urine. Long-term use has been shown to significantly reduce serum and tissue zinc levels, potentially causing taste disturbances, impaired wound healing, and immune dysfunction.
Evidence
Evidence level: strong.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 10,141 reports mentioning Captopril. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Captopril + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Zinc interactions → · All Captopril interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.