Is CoQ10 (Ubiquinone) Safe with Captopril?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
CoQ10 supplementation (100-200mg/day) may be used alongside Captopril but monitor blood pressure closely, especially when initiating CoQ10. Inform your physician before starting CoQ10.
Why this interaction occurs
CoQ10 has demonstrated modest antihypertensive properties in clinical trials, with reductions of approximately 10-17 mmHg systolic in some studies. When combined with Captopril, there is potential for additive blood pressure lowering, which could cause hypotension in susceptible patients. However, CoQ10 also offers cardioprotective benefits and may counteract drug-induced CoQ10 reductions seen with some cardiovascular medications.
Evidence
Evidence level: limited.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 10,141 reports mentioning Captopril. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Captopril + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All CoQ10 (Ubiquinone) interactions → · All Captopril interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.