Is CoQ10 (Ubiquinone) Safe with Lisinopril?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
CoQ10 supplementation (100-200 mg/day) is generally well tolerated with lisinopril but may provide additional blood pressure reduction. Monitor blood pressure closely when initiating CoQ10. Inform your healthcare provider before starting supplementation.
Why this interaction occurs
CoQ10 has demonstrated modest antihypertensive effects in clinical trials, potentially through improved endothelial function and vascular smooth muscle relaxation. When combined with lisinopril, additive hypotensive effects are possible, though serious adverse interactions are not well documented. Some evidence also suggests ACE inhibitors may modestly deplete CoQ10 via mitochondrial pathway alterations.
Evidence
Evidence level: limited.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 323,131 reports mentioning Lisinopril. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Lisinopril + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All CoQ10 (Ubiquinone) interactions → · All Lisinopril interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.