Is White Willow Safe with Aspirin?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Avoid combining Aspirin with White Willow Bark. Taking both increases total salicylate load, raising the risk of tinnitus, GI bleeding, and salicylate toxicity. Consult your doctor before using either.
Why this interaction occurs
Both Aspirin and White Willow Bark share the same active salicylate pathway. Concurrent use creates additive pharmacodynamic effects, increasing gastrointestinal irritation, antiplatelet activity, and risk of salicylism.
Evidence
Evidence level: strong.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 617,935 reports mentioning Aspirin. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Aspirin + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All White Willow interactions → · All Aspirin interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.