Is White Willow Safe with Clopidogrel?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Avoid White Willow Bark if you are taking Clopidogrel. The combination significantly increases the risk of serious bleeding. If you are using both, contact your doctor immediately. Do not discontinue Clopidogrel without medical advice.
Why this interaction occurs
Clopidogrel inhibits ADP-mediated platelet aggregation, while White Willow's salicylates inhibit thromboxane A2-mediated platelet activation. Combined use results in dual antiplatelet blockade with substantially elevated hemorrhage risk.
Evidence
Evidence level: strong.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 108,615 reports mentioning Clopidogrel. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Clopidogrel + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All White Willow interactions → · All Clopidogrel interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.