Is Berberine Safe with Apixaban?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Avoid combining Berberine with Apixaban — Berberine blocks the liver enzyme (CYP3A4) that processes Apixaban, potentially raising Apixaban levels to toxic range. Consult your doctor or pharmacist.
Why this interaction occurs
Berberine inhibits intestinal CYP3A4. Result: increased drug levels. Monitor drug levels when combining with CYP3A4 substrates
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 67,478 reports mentioning Apixaban. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Apixaban + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Berberine interactions → · All Apixaban interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.