Is Echinacea Safe with Apixaban?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Use caution combining Echinacea with Apixaban. Echinacea may mildly speed up Apixaban metabolism via CYP3A4. Monitor for reduced effectiveness.
Why this interaction occurs
Echinacea modestly induces hepatic CYP3A4. Result: slightly decreased drug levels. Low clinical risk for most drugs but avoid with immunosuppressants
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 67,478 reports mentioning Apixaban. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Apixaban + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Echinacea interactions → · All Apixaban interactions →
Already checked this one — check your whole list
Educational only — not medical advice.
Always confirm with your doctor or pharmacist.