Is Magnesium Safe with Vyvanse?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Take magnesium supplements at least 2 hours after Vyvanse. Avoid high-dose magnesium (>400mg elemental/day) unless prescribed, and report symptoms of prolonged stimulant effect such as insomnia or elevated heart rate.
Why this interaction occurs
This can extend the drug's half-life and increase systemic exposure, potentially intensifying side effects including cardiovascular effects and insomnia.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 28,912 reports mentioning Vyvanse. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Vyvanse + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Magnesium interactions → · All Vyvanse interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.